Stomach
Table of Contents
Definition of Stomach
The stomach is a hollow J – shaped organ situated just below the diaphragm on the left side of abdominal cavity. It produces enzymes (substances that create chemical reactions) and acid (digestive juices).

Volume of stomach
The volume of the empty stomach is 50 mL. Under normal conditions, it can expand to accommodate 1 L to 1.5 L of solids and liquids. However, it’s capable of expanding still further up to 4 L.
What are the parts of the stomach?
In humans, the stomach has four parts:
1. Cardiac region
2. Fundus
3. Body or corpus
4. Pyloric region.
Cardiac region
The cardiac region is the upper part of the stomach where the esophagus opens. The opening is guarded by a sphincter called the cardiac sphincter, which opens only towards stomach.
Fundus
The fundus is a small dome shaped structure. It is elevated above level of esophageal opening.
Body or Corpus
The body is largest part of stomach forming about 75% to 80% of the whole stomach.
Pyloric Region
The pyloric region has two parts, the antrum and the pyloric canal.
The body of the stomach ends in an antrum. Pyloric
canal opens into first part of the small intestine called the duodenum.
Curvature of Stomach
The stomach has two curvatures. One on the right side is less curvature and the other on the left side is greater curvature.
What is the structure of the stomach wall?
The stomach wall is formed by four layers of structures:
1. Outer serous layer: Formed by peritoneum
2. Muscular layer: Made up of 3 layers of smooth muscle fibers, namely inner oblique, middle circular, and outer longitudinal layers
3. Sub-mucus layer: Formed by areolar tissue, blood vessels, lymph vessels, and Meissner nerve plexus.
4. Inner mucus layer: Lined by mucus-secreting columnar epithelial cell. The gastric gland are situated in this layer.
What are the glands in stomach?

Gastric glands in the stomach are classified into three types
- Fundic glands or main gastric glands or oxyntic glands: Situated in the body and fundus of the stomach
- Pyloric glands: Present in pyloric part of the stomach
- Cardiac glands: Located in the cardiac region of the
stomach.
What are the functions of the stomach?
Storage Function
Food is stored in the stomach for a long period, i.e. for 3 to 4 hours, and emptied into the intestine slowly. The maximum capacity of the stomach is up to 1.5 L.
Formation of Chyme
Peristaltic movements of stomach mix the bolus with gastric juice and convert it into semisolid material known as chyme.
Digestive function
Gastric juice acts mainly on proteins. Proteolytic enzyme of gastric juice are pepsin and rennin. they help in digestion.
Protective function
Mucus help in protection of inner linning of stomach from HCL .
Excretory function
Many substances like toxin, alkaloids and metals are excreted through gastric juice.
Homepoietic function
Intrinsic factor of Castle, secreted by parietal cells of gastric glands plays important role in erythropoiesis. It is necessary for the absorption of vitamin B12 (which is called an extrinsic factor) from the GI tract into the blood
What are the disorders of the stomach?
- Gastrointestinal diseases may affect your stomach.
- Gastric ulcers: Erosion in your stomach’s lining that can lead to the pain and bleeding.
- Peptic ulcer disease: Ulcers (sores) in either your stomach or first portion of your small intestine (duodenum).
- Stomach cancer: When cancerous cell grow uncontrollably in your stomach.
- Indigestion (dyspepsia): Discomfort, pain or burning in your upper stomach.
How to keep your stomach healthy?
If you want to keep your stomach healthy then initially change your lifestyle to keep your stomach and digestive system healthy.
- Drink alcohol only in moderation.
- Drink at least 50 ounces of water daily, depending on your activity levels and size.
- Eat 25 to 35 grams of fiber
- limit your intake of food
- Management of stress
- Quit smoking
- Exercise regularly.

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